Recent Publications from the New England National Primate Research Center (center closed as of 5/31/15)

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Duke AN, Platt DM, Rowlett JK
Tolerance and dependence following chronic alprazolam treatment: quantitativeobservation studies in female rhesus monkeys.
Psychopharmacology (Berl). 2020 Apr;237(4):1183-1194. doi:10.1007/s00213-019-05447-1. Epub 2020 Jan 11.

Ensser A, Yasuda K, Lauer W, Desrosiers RC, Hahn AS
Rhesus Monkey Rhadinovirus Isolated from Hemangioma Tissue.
Microbiol Resour Announc. 2020 Mar 19;9(12). pii: 9/12/e01347-19. doi:10.1128/MRA.01347-19.

Meng Z, Berro LF, Sawyer EK, Ruedi-Bettschen D, Cook JE, Li G, Platt DM, Cook JM, Rowlett JK
Evaluation of the anti-conflict, reinforcing, and sedative effects of YT-III-31, a ligand functionally selective for alpha3 subunit-containing GABAA receptors.
J Psychopharmacol. 2020 Mar;34(3):348-357. doi: 10.1177/0269881119882803. Epub2019 Oct 31.

Almodovar S, Swanson J, Giavedoni LD, Kanthaswamy S, Long CS, Voelkel NF, Edwards MG, Folkvord JM, Connick E, Westmoreland SV, Luciw PA, Flores SC
Lung Vascular Remodeling, Cardiac Hypertrophy, and Inflammatory Cytokines inSHIVnef-Infected Macaques.
Viral Immunol. 2018 Apr;31(3):206-222. doi: 10.1089/vim.2017.0051. Epub 2017 Dec 19.

Cavicchioli L, Ferraresso S, Westmoreland S, Kaliyaperumal S, Knight H, Crossan C, Scobie L, Danesi A, Vadori M, Trez D, Badin RA, Hantraye P, Cozzi E
Posttransplant Lymphoproliferative Disorders in Neuronal XenotransplantedMacaques.
Vet Pathol. 2017 Mar;54(2):336-344. doi: 10.1177/0300985816669407. Epub 2016 Oct 1.

Chandler CM, Follett ME, Porter NJ, Liang KY, Vallender EJ, Miller GM, Rowlett JK, Platt DM
Persistent negative effects of alcohol drinking on aspects of novelty-directedbehavior in male rhesus macaques.
Alcohol. 2017 Sep;63:19-26. doi: 10.1016/j.alcohol.2017.03.002. Epub 2017 Jun 23.

Golebiowski D, van der Bom IMJ, Kwon CS, Miller AD, Petrosky K, Bradbury AM, Maitland S, Kuhn AL, Bishop N, Curran E, Silva N, GuhaSarkar D, Westmoreland SV, Martin DR, Gounis MJ, Asaad WF, Sena-Esteves M
Direct Intracranial Injection of AAVrh8 Encoding Monkeybeta-N-Acetylhexosaminidase Causes Neurotoxicity in the Primate Brain.
Hum Gene Ther. 2017 Jun;28(6):510-522. doi: 10.1089/hum.2016.109. Epub 2017 Jan26.

Gonzalez-Perez MP, Peters PJ, O'Connell O, Silva N, Harbison C, Cummings Macri S, Kaliyaperumal S, Luzuriaga K, Clapham PR
Identification of Emerging Macrophage-Tropic HIV-1 R5 Variants in Brain Tissue ofAIDS Patients without Severe Neurological Complications.
J Virol. 2017 Sep 27;91(20). pii: JVI.00755-17. doi: 10.1128/JVI.00755-17. Print 2017 Oct 15.

Guo W, Pencina KM, O'Connell K, Montano M, Peng L, Westmoreland S, Glowacki J, Bhasin S
Administration of an activin receptor IIB ligand trap protects male juvenilerhesus macaques from simian immunodeficiency virus-associated bone loss.
Bone. 2017 Apr;97:209-215. doi: 10.1016/j.bone.2017.01.032. Epub 2017 Jan 26.

Lu W, Wan Y, Ma F, Johnson RP, Li Q
Distinct transcriptome profiles of Gag-specific CD8+ T cells temporallycorrelated with the protection elicited by SIVDeltanef live attenuated vaccine.
PLoS One. 2017 Mar 23;12(3):e0173929. doi: 10.1371/journal.pone.0173929.eCollection 2017.

Ma Q, Ruan H, Peng L, Zhang M, Gack MU, Yao WD
Proteasome-independent polyubiquitin linkage regulates synapse scaffolding,efficacy, and plasticity.
Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8760-E8769. doi:10.1073/pnas.1620153114. Epub 2017 Sep 25.

Manickam C, Wachtman L, Martinot AJ, Giavedoni LD, Reeves RK
Metabolic Dysregulation in Hepacivirus Infection of Common Marmosets (Callithrix jacchus).
PLoS One. 2017 Jan 13;12(1):e0170240. doi: 10.1371/journal.pone.0170240.eCollection 2017.

Rahmberg AR, Rajakumar PA, Billingsley JM, Johnson RP
Dynamic Modulation of Expression of Lentiviral Restriction Factors in PrimaryCD4(+) T Cells following Simian Immunodeficiency Virus Infection.
J Virol. 2017 Mar 13;91(7). pii: JVI.02189-16. doi: 10.1128/JVI.02189-16. Print2017 Apr 1.

Ruan H, Yao WD
Cocaine Promotes Coincidence Detection and Lowers Induction Threshold duringHebbian Associative Synaptic Potentiation in Prefrontal Cortex.
J Neurosci. 2017 Jan 25;37(4):986-997. doi: 10.1523/JNEUROSCI.2257-16.2016.

Sweeney CG, Rando JM, Panas HN, Miller GM, Platt DM, Vallender EJ
Convergent Balancing Selection on the Mu-Opioid Receptor in Primates.
Mol Biol Evol. 2017 Jul 1;34(7):1629-1643. doi: 10.1093/molbev/msx105.

Vallender EJ, Goswami DB, Shinday NM, Westmoreland SV, Yao WD, Rowlett JK
Transcriptomic profiling of the ventral tegmental area and nucleus accumbens inrhesus macaques following long-term cocaine self-administration.
Drug Alcohol Depend. 2017 Jun 1;175:9-23. doi: 10.1016/j.drugalcdep.2017.01.030. Epub 2017 Mar 18.

Adnan S, Reeves RK, Gillis J, Wong FE, Yu Y, Camp JV, Li Q, Connole M, Li Y, Piatak M Jr, Lifson JD, Li W, Keele BF, Kozlowski PA, Desrosiers RC, Haase AT, Johnson RP
Persistent Low-Level Replication of SIVDeltanef Drives Maturation of Antibody andCD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection.
PLoS Pathog. 2016 Dec 13;12(12):e1006104. doi: 10.1371/journal.ppat.1006104.eCollection 2016 Dec.

Banton SA, Soltow QA, Liu KH, Uppal K, Promislow DE, Power ML, Tardif SD, Wachtman LM, Jones DP
Plasma Metabolomics of Common Marmosets (Callithrix jacchus) to Evaluate Diet andFeeding Husbandry.
J Am Assoc Lab Anim Sci. 2016 Mar;55(2):137-46.

Barouch DH, Ghneim K, Bosche WJ, Li Y, Berkemeier B, Hull M, Bhattacharyya S, Cameron M, Liu J, Smith K, Borducchi E, Cabral C, Peter L, Brinkman A, Shetty M, Li H, Gittens C, Baker C, Wagner W, Lewis MG, Colantonio A, Kang HJ, Li W, Lifson JD, Piatak M Jr, Sekaly RP
Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys.
Cell. 2016 Apr 21;165(3):656-67. doi: 10.1016/j.cell.2016.03.021. Epub 2016 Apr13.

Eberhard JM, Ahmad F, Hong HS, Bhatnagar N, Keudel P, Schulze Zur Wiesch J, Schmidt RE, Meyer-Olson D
Partial recovery of senescence and differentiation disturbances in CD8(+) T cell effector-memory cells in HIV-1 infection after initiation of anti-retroviral treatment.
Clin Exp Immunol. 2016 Nov;186(2):227-238. doi: 10.1111/cei.12837. Epub 2016 Aug 23.

Evans TI, Li H, Schafer JL, Klatt NR, Hao XP, Traslavina RP, Estes JD, Brenchley JM, Reeves RK
SIV-induced Translocation of Bacterial Products in the Liver Mobilizes MyeloidDendritic and Natural Killer Cells Associated With Liver Damage.
J Infect Dis. 2016 Feb 1;213(3):361-9. doi: 10.1093/infdis/jiv404. Epub 2015 Aug 3.

Fischer BD, Platt DM, Rallapalli SK, Namjoshi OA, Cook JM, Rowlett JK
Antagonism of triazolam self-administration in rhesus monkeys responding under a progressive-ratio schedule: In vivo apparent pA2 analysis.
Drug Alcohol Depend. 2016 Jan 1;158:22-9. doi: 10.1016/j.drugalcdep.2015.10.026. Epub 2015 Oct 30.

Harbison CE, Lipman RD, Bronson RT
Strain- and Diet-Related Lesion Variability in Aging DBA/2, C57BL/6, andDBA/2xC57BL/6 F1 Mice.
Vet Pathol. 2016 Mar;53(2):468-76. doi: 10.1177/0300985815612152. Epub 2015 Nov24.

Hoffman JM, Tran V, Wachtman LM, Green CL, Jones DP, Promislow DE
A longitudinal analysis of the effects of age on the blood plasma metabolome inthe common marmoset, Callithrix jacchus.
Exp Gerontol. 2016 Apr;76:17-24. doi: 10.1016/j.exger.2016.01.007. Epub 2016 Jan 21.

Hong HS, Koch SD, Scheel B, Gnad-Vogt U, Schroder A, Kallen KJ, Wiegand V, Backert L, Kohlbacher O, Hoerr I, Fotin-Mleczek M, Billingsley JM
Distinct transcriptional changes in non-small cell lung cancer patientsassociated with multi-antigenic RNActive(R) CV9201 immunotherapy.
Oncoimmunology. 2016 Nov 18;5(12):e1249560. doi: 10.1080/2162402X.2016.1249560.eCollection 2016.

Keating SM, Heitman JW, Wu S, Deng X, Stacey AR, Zahn RC, de la Rosa M, Finstad SL, Lifson JD, Piatak M Jr, Gauduin MC, Kessler BM, Ternette N, Carville A, Johnson RP, Desrosiers RC, Letvin NL, Borrow P, Norris PJ, Schmitz JE
Magnitude and Quality of Cytokine and Chemokine Storm during Acute InfectionDistinguish Nonprogressive and Progressive Simian Immunodeficiency Virus Infections of Nonhuman Primates.
J Virol. 2016 Oct 28;90(22):10339-10350. doi: 10.1128/JVI.01061-16. Print 2016Nov 15.

Manickam C, Rajakumar P, Wachtman L, Kramer JA, Martinot AJ, Varner V, Giavedoni LD, Reeves RK
Acute Liver Damage Associated with Innate Immune Activation in a Small NonhumanPrimate Model of Hepacivirus Infection.
J Virol. 2016 Sep 29;90(20):9153-62. doi: 10.1128/JVI.01051-16. Print 2016 Oct15.

Meng Z, Rowlett JK
Self-administration of progesterone and synthetic neuroactive steroids by malerhesus monkeys.
Drug Alcohol Depend. 2016 Aug 1;165:265-9. doi: 10.1016/j.drugalcdep.2016.05.029.Epub 2016 Jun 8.

Saur T, Cohen BM, Ma Q, Babb SM, Buttner EA, Yao WD
Acute and chronic effects of clozapine on cholinergic transmission in culturedmouse superior cervical ganglion neurons.
J Neurogenet. 2016 Sep - Dec;30(3-4):297-305. doi: 10.1080/01677063.2016.1229779.Epub 2016 Sep 14.

Saur T, Peng IF, Jiang P, Gong N, Yao WD, Xu TL, Wu CF
K(+) channel reorganization and homeostatic plasticity during postembryonicdevelopment: biophysical and genetic analyses in acutely dissociated Drosophila central neurons.
J Neurogenet. 2016 Sep - Dec;30(3-4):259-275. doi: 10.1080/01677063.2016.1255212.Epub 2016 Nov 21.

Wharton KA Jr, Quigley C, Themeles M, Dunstan RW, Doyle K, Cahir-McFarland E, Wei J, Buko A, Reid CE, Sun C, Carmillo P, Sur G, Carulli JP, Mansfield KG, Westmoreland SV, Staugaitis SM, Fox RJ, Meier W, Goelz SE
JC Polyomavirus Abundance and Distribution in Progressive MultifocalLeukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection.
PLoS One. 2016 May 18;11(5):e0155897. doi: 10.1371/journal.pone.0155897.eCollection 2016.

Zeng M, Smith AJ, Shang L, Wietgrefe SW, Voss JE, Carlis JV, Li Q, Piatak M Jr, Lifson JD, Johnson RP, Haase AT
Mucosal Humoral Immune Response to SIVmac239nef Vaccination and VaginalChallenge.
J Immunol. 2016 Mar 15;196(6):2809-18. doi: 10.4049/jimmunol.1500156. Epub 2016Feb 10.

von Bredow B, Arias JF, Heyer LN, Moldt B, Le K, Robinson JE, Zolla-Pazner S, Burton DR, Evans DT
Comparison of Antibody-Dependent Cell-Mediated Cytotoxicity and VirusNeutralization by HIV-1 Env-Specific Monoclonal Antibodies.
J Virol. 2016 Jun 10;90(13):6127-6139. doi: 10.1128/JVI.00347-16. Print 2016 Jul 1.

Adnan S, Colantonio AD, Yu Y, Gillis J, Wong FE, Becker EA, Piatak M Jr, Reeves RK, Lifson JD, O'Connor SL, Johnson RP
CD8 T cell response maturation defined by anentropic specificity and repertoiredepth correlates with SIVDeltanef-induced protection.
PLoS Pathog. 2015 Feb 17;11(2):e1004633. doi: 10.1371/journal.ppat.1004633.eCollection 2015 Feb.

Assaf BT, Knight HL, Miller AD
rhesus cytomegalovirus (macacine herpesvirus 3)-associated facial neuritis insimian immunodeficiency virus-infected rhesus macaques (Macaca mulatta).
Vet Pathol. 2015 Jan;52(1):217-23. doi: 10.1177/0300985814529313. Epub 2014 Mar31.

Barouch DH, Alter G, Broge T, Linde C, Ackerman ME, Brown EP, Borducchi EN, Smith KM, Nkolola JP, Liu J, Shields J, Parenteau L, Whitney JB, Abbink P, Ng'ang'a DM, Seaman MS, Lavine CL, Perry JR, Li W, Colantonio AD, Lewis MG, Chen B, Wenschuh H, Reimer U, Piatak M, Lifson JD, Handley SA, Virgin HW, Koutsoukos M, Lorin C, Voss G, Weijtens M, Pau MG, Schuitemaker H
Protective efficacy of adenovirus/protein vaccines against SIV challenges inrhesus monkeys.
Science. 2015 Jul 17;349(6245):320-4. doi: 10.1126/science.aab3886. Epub 2015 Jul2.

Bialas KM, Tanaka T, Tran D, Varner V, Cisneros De La Rosa E, Chiuppesi F, Wussow F, Kattenhorn L, Macri S, Kunz EL, Estroff JA, Kirchherr J, Yue Y, Fan Q, Lauck M, O'Connor DH, Hall AH, Xavier A, Diamond DJ, Barry PA, Kaur A, Permar SR
Maternal CD4+ T cells protect against severe congenital cytomegalovirus diseasein a novel nonhuman primate model of placental cytomegalovirus transmission.
Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13645-50. doi:10.1073/pnas.1511526112. Epub 2015 Oct 19.

Billingsley JM, Rajakumar PA, Connole MA, Salisch NC, Adnan S, Kuzmichev YV, Hong HS, Reeves RK, Kang HJ, Li W, Li Q, Haase AT, Johnson RP
Characterization of CD8+ T cell differentiation following SIVDeltanef vaccinationby transcription factor expression profiling.
PLoS Pathog. 2015 Mar 13;11(3):e1004740. doi: 10.1371/journal.ppat.1004740.eCollection 2015 Mar.

Bouts MJ, Westmoreland SV, de Crespigny AJ, Liu Y, Vangel M, Dijkhuizen RM, Wu O, D'Arceuil HE
Magnetic resonance imaging-based cerebral tissue classification reveals distinct spatiotemporal patterns of changes after stroke in non-human primates.
BMC Neurosci. 2015 Dec 15;16:91. doi: 10.1186/s12868-015-0226-7.

Chronopoulos A, Roy S, Beglova E, Mansfield K, Wachtman L, Roy S
Hyperhexosemia-Induced Retinal Vascular Pathology in a Novel Primate Model ofDiabetic Retinopathy.
Diabetes. 2015 Jul;64(7):2603-8. doi: 10.2337/db14-0866. Epub 2015 Mar 2.

Gardner MR, Kattenhorn LM, Kondur HR, von Schaewen M, Dorfman T, Chiang JJ, Haworth KG, Decker JM, Alpert MD, Bailey CC, Neale ES Jr, Fellinger CH, Joshi VR, Fuchs SP, Martinez-Navio JM, Quinlan BD, Yao AY, Mouquet H, Gorman J, Zhang B, Poignard P, Nussenzweig MC, Burton DR, Kwong PD, Piatak M Jr, Lifson JD, Gao G, Desrosiers RC, Evans DT, Hahn BH, Ploss A, Cannon PM, Seaman MS, Farzan M
AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges.
Nature. 2015 Mar 5;519(7541):87-91. doi: 10.1038/nature14264. Epub 2015 Feb 18.

Go YM, Liang Y, Uppal K, Soltow QA, Promislow DE, Wachtman LM, Jones DP
Metabolic Characterization of the Common Marmoset (Callithrix jacchus).
PLoS One. 2015 Nov 18;10(11):e0142916. doi: 10.1371/journal.pone.0142916.eCollection 2015.

Hallett PJ, Deleidi M, Astradsson A, Smith GA, Cooper O, Osborn TM, Sundberg M, Moore MA, Perez-Torres E, Brownell AL, Schumacher JM, Spealman RD, Isacson O
Successful function of autologous iPSC-derived dopamine neurons followingtransplantation in a non-human primate model of Parkinson's disease.
Cell Stem Cell. 2015 Mar 5;16(3):269-74. doi: 10.1016/j.stem.2015.01.018. Epub2015 Feb 26.

Harbison CE, Taheri F, Knight H, Miller AD
Immunohistochemical Characterization of Large Intestinal Adenocarcinoma in theRhesus Macaque (Macaca mulatta).
Vet Pathol. 2015 Jul;52(4):732-40. doi: 10.1177/0300985814556188. Epub 2014 Nov3.

Holzemer A, Thobakgale CF, Jimenez Cruz CA, Garcia-Beltran WF, Carlson JM, van Teijlingen NH, Mann JK, Jaggernath M, Kang SG, Korner C, Chung AW, Schafer JL, Evans DT, Alter G, Walker BD, Goulder PJ, Carrington M, Hartmann P, Pertel T, Zhou R, Ndung'u T, Altfeld M
Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant IsAssociated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa.
PLoS Med. 2015 Nov 17;12(11):e1001900; discussion e1001900. doi:10.1371/journal.pmed.1001900. eCollection 2015 Nov.

Hou Q, Ruan H, Gilbert J, Wang G, Ma Q, Yao WD, Man HY
MicroRNA miR124 is required for the expression of homeostatic synapticplasticity.
Nat Commun. 2015 Dec 1;6:10045. doi: 10.1038/ncomms10045.

Kaliyaperumal S, Wuthrich C, Westmoreland SV, Koralnik IJ
Simian Virus 40 Infection in the Spinal Cord of Simian ImmunodeficiencyVirus-Immunosuppressed Rhesus Macaques.
J Neuropathol Exp Neurol. 2015 Nov;74(11):1071-6. doi:10.1097/NEN.0000000000000252.

Kramer JA, Grindley J, Crowell AM, Makaron L, Kohli R, Kirby M, Mansfield KG, Wachtman LM
The common marmoset as a model for the study of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Vet Pathol. 2015 Mar;52(2):404-13. doi: 10.1177/0300985814537839. Epub 2014 Jun9.

Li H, Evans TI, Gillis J, Connole M, Reeves RK
Bone marrow-imprinted gut-homing of plasmacytoid dendritic cells (pDCs) in acute simian immunodeficiency virus infection results in massive accumulation of hyperfunctional CD4+ pDCs in the mucosae.
J Infect Dis. 2015 Jun 1;211(11):1717-25. doi: 10.1093/infdis/jiu671. Epub 2014Dec 8.

O'Connell KE, Guo W, Serra C, Beck M, Wachtman L, Hoggatt A, Xia D, Pearson C, Knight H, O'Connell M, Miller AD, Westmoreland SV, Bhasin S
The effects of an ActRIIb receptor Fc fusion protein ligand trap in juvenilesimian immunodeficiency virus-infected rhesus macaques.
FASEB J. 2015 Apr;29(4):1165-75. doi: 10.1096/fj.14-257543. Epub 2014 Dec 2.

O'Connell KE, Mikkola AM, Stepanek AM, Vernet A, Hall CD, Sun CC, Yildirim E, Staropoli JF, Lee JT, Brown DE
Practical murine hematopathology: a comparative review and implications forresearch.
Comp Med. 2015 Apr;65(2):96-113.

Reeves RK, Li H, Jost S, Blass E, Li H, Schafer JL, Varner V, Manickam C, Eslamizar L, Altfeld M, von Andrian UH, Barouch DH
Antigen-specific NK cell memory in rhesus macaques.
Nat Immunol. 2015 Sep;16(9):927-32. doi: 10.1038/ni.3227. Epub 2015 Jul 20.

Ruedi-Bettschen D, Spealman RD, Platt DM
Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys by direct and indirect activation of 5-HT2C receptors.
Psychopharmacology (Berl). 2015 Aug;232(16):2959-68. doi:10.1007/s00213-015-3932-z. Epub 2015 Apr 17.

Schafer JL, Li H, Evans TI, Estes JD, Reeves RK
Accumulation of Cytotoxic CD16+ NK Cells in Simian ImmunodeficiencyVirus-Infected Lymph Nodes Associated with In Situ Differentiation and Functional Anergy.
J Virol. 2015 Jul;89(13):6887-94. doi: 10.1128/JVI.00660-15. Epub 2015 Apr 22.

Schafer JL, Ries M, Guha N, Connole M, Colantonio AD, Wiertz EJ, Wilson NA, Kaur A, Evans DT
Suppression of a Natural Killer Cell Response by Simian Immunodeficiency VirusPeptides.
PLoS Pathog. 2015 Sep 2;11(9):e1005145. doi: 10.1371/journal.ppat.1005145.eCollection 2015 Sep.

Stansell E, Panico M, Canis K, Pang PC, Bouche L, Binet D, O'Connor MJ, Chertova E, Bess J, Lifson JD, Haslam SM, Morris HR, Desrosiers RC, Dell A
Gp120 on HIV-1 Virions Lacks O-Linked Carbohydrate.
PLoS One. 2015 Apr 27;10(4):e0124784. doi: 10.1371/journal.pone.0124784.eCollection 2015.

Uppal K, Soltow QA, Promislow DE, Wachtman LM, Quyyumi AA, Jones DP
MetabNet: An R Package for Metabolic Association Analysis of High-ResolutionMetabolomics Data.
Front Bioeng Biotechnol. 2015 Jun 11;3:87. doi: 10.3389/fbioe.2015.00087.eCollection 2015.

Wang Z, Metcalf B, Kasheta M, Kasala-Hallinan C, Tran D, Johnson RP, Else JG, Karl J, O'Connor D, Apetrei C, Kaur A
Characterization of MHC class I alleles in sooty mangabeys as a tool forevaluating cellular immunity in natural hosts of SIV infection.
Immunogenetics. 2015 Aug;67(8):447-61. doi: 10.1007/s00251-015-0853-2. Epub 2015 Jul 1.

Yasuda K, Oh K, Ren B, Tickle TL, Franzosa EA, Wachtman LM, Miller AD, Westmoreland SV, Mansfield KG, Vallender EJ, Miller GM, Rowlett JK, Gevers D, Huttenhower C, Morgan XC
Biogeography of the intestinal mucosal and lumenal microbiome in the rhesusmacaque.
Cell Host Microbe. 2015 Mar 11;17(3):385-391. doi: 10.1016/j.chom.2015.01.015.Epub 2015 Feb 26.

von Bredow B, Arias JF, Heyer LN, Gardner MR, Farzan M, Rakasz EG, Evans DT
Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity.
J Virol. 2015 Oct;89(20):10648-55. doi: 10.1128/JVI.01911-15. Epub 2015 Aug 12.

Abdel-Motal UM, Harbison C, Han T, Pudney J, Anderson DJ, Zhu Q, Westmoreland S, Marasco WA
Prolonged expression of an anti-HIV-1 gp120 minibody to the female rhesus macaquelower genital tract by AAV gene transfer.
Gene Ther. 2014 Sep;21(9):802-10. doi: 10.1038/gt.2014.56. Epub 2014 Jun 26.

Ahmad F, Hong HS, Jackel M, Jablonka A, Lu IN, Bhatnagar N, Eberhard JM, Bollmann BA, Ballmaier M, Zielinska-Skowronek M, Schmidt RE, Meyer-Olson D
High frequencies of polyfunctional CD8+ NK cells in chronic HIV-1 infection areassociated with slower disease progression.
J Virol. 2014 Nov;88(21):12397-408. doi: 10.1128/JVI.01420-14. Epub 2014 Aug 13.

Antoine P, Varner V, Carville A, Connole M, Marchant A, Kaur A
Postnatal acquisition of primary rhesus cytomegalovirus infection is associatedwith prolonged virus shedding and impaired CD4+ T lymphocyte function.
J Infect Dis. 2014 Oct 1;210(7):1090-9. doi: 10.1093/infdis/jiu215. Epub 2014 Apr8.

Arias JF, Heyer LN, von Bredow B, Weisgrau KL, Moldt B, Burton DR, Rakasz EG, Evans DT
Tetherin antagonism by Vpu protects HIV-infected cells from antibody-dependentcell-mediated cytotoxicity.
Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6425-30. doi:10.1073/pnas.1321507111. Epub 2014 Apr 14.

Assaf BT, Mansfield KG, Strelow L, Westmoreland SV, Barry PA, Kaur A
Limited dissemination and shedding of the UL128 complex-intact, UL/b'-defectiverhesus cytomegalovirus strain 180.92.
J Virol. 2014 Aug;88(16):9310-20. doi: 10.1128/JVI.00162-14. Epub 2014 Jun 4.

Davis ME, Wang MK, Rennick LJ, Full F, Gableske S, Mesman AW, Gringhuis SI, Geijtenbeek TB, Duprex WP, Gack MU
Antagonism of the phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5.
Cell Host Microbe. 2014 Jul 9;16(1):19-30. doi: 10.1016/j.chom.2014.06.007.

Faraone SV, Spencer TJ, Madras BK, Zhang-James Y, Biederman J
Functional effects of dopamine transporter gene genotypes on in vivo dopaminetransporter functioning: a meta-analysis.
Mol Psychiatry. 2014 Aug;19(8):880-9. doi: 10.1038/mp.2013.126. Epub 2013 Sep 24.

Faraone SV, Spencer TJ, Madras BK, Zhang-James Y, Biederman J
Response to Selveraj et al.
Mol Psychiatry. 2014 Sep;19(9):964-5. doi: 10.1038/mp.2014.26. Epub 2014 Apr 1.

Gascon E, Lynch K, Ruan H, Almeida S, Verheyden JM, Seeley WW, Dickson DW, Petrucelli L, Sun D, Jiao J, Zhou H, Jakovcevski M, Akbarian S, Yao WD, Gao FB
Alterations in microRNA-124 and AMPA receptors contribute to social behavioraldeficits in frontotemporal dementia.
Nat Med. 2014 Dec;20(12):1444-51. doi: 10.1038/nm.3717. Epub 2014 Nov 17.

George MD, Hu W, Billingsley JM, Reeves RK, Sankaran-Walters S, Johnson RP, Dandekar S
Transcriptional profiling of peripheral CD8+T cell responses to SIVDeltanef andSIVmac251 challenge reveals a link between protective immunity and induction of systemic immunoregulatory mechanisms.
Virology. 2014 Nov;468-470:581-591. doi: 10.1016/j.virol.2014.09.013. Epub 2014Oct 1.

Harbison C, Zhuang K, Gettie A, Blanchard J, Knight H, Didier P, Cheng-Mayer C, Westmoreland S
Giant cell encephalitis and microglial infection with mucosally transmittedsimian-human immunodeficiency virus SHIVSF162P3N in rhesus macaques.
J Neurovirol. 2014 Feb;20(1):62-72. doi: 10.1007/s13365-013-0229-z. Epub 2014 Jan25.

Hartwell HJ, Petrosky KY, Fox JG, Horseman ND, Rogers AB
Prolactin prevents hepatocellular carcinoma by restricting innate immuneactivation of c-Myc in mice.
Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11455-60. doi:10.1073/pnas.1404267111. Epub 2014 Jul 21.

Kaliyaperumal S, Watkins B, Sharma P, Furlan S, Ramakrishnan S, Giver C, Garcia A, Courtney C, Knight H, Strobert E, Elder E, Crenshaw T, Blazar BR, Waller EK, Westmoreland S, Kean LS
CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and isimproved with immunoprophylaxis.
Blood. 2014 Mar 20;123(12):1967-9. doi: 10.1182/blood-2014-01-547612.

Kelly B, Maguire-Herring V, Rose CM, Gore HE, Ferrigno S, Novak MA, Lacreuse A
Short-term testosterone manipulations do not affect cognition or motor functionbut differentially modulate emotions in young and older male rhesus monkeys.
Horm Behav. 2014 Nov;66(5):731-42. doi: 10.1016/j.yhbeh.2014.08.016. Epub 2014Oct 13.

Lee H, Park JH, Seo I, Park SH, Kim S
Improved application of the electrophoretic tissue clearing technology, CLARITY, to intact solid organs including brain, pancreas, liver, kidney, lung, and intestine.
BMC Dev Biol. 2014 Dec 21;14:48. doi: 10.1186/s12861-014-0048-3.

Lee K, Zhong X, Gu S, Kruel AM, Dorner MB, Perry K, Rummel A, Dong M, Jin R
Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin Acomplex.
Science. 2014 Jun 20;344(6190):1405-10. doi: 10.1126/science.1253823.

Li H, Richert-Spuhler LE, Evans TI, Gillis J, Connole M, Estes JD, Keele BF, Klatt NR, Reeves RK
Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIVinfection.
PLoS Pathog. 2014 Dec 11;10(12):e1004551. doi: 10.1371/journal.ppat.1004551.eCollection 2014 Dec.

Li Q, Zeng M, Duan L, Voss JE, Smith AJ, Pambuccian S, Shang L, Wietgrefe S, Southern PJ, Reilly CS, Skinner PJ, Zupancic ML, Carlis JV, Piatak M Jr, Waterman D, Reeves RK, Masek-Hammerman K, Derdeyn CA, Alpert MD, Evans DT, Kohler H, Muller S, Robinson J, Lifson JD, Burton DR, Johnson RP, Haase AT
Live simian immunodeficiency virus vaccine correlate of protection: localantibody production and concentration on the path of virus entry.
J Immunol. 2014 Sep 15;193(6):3113-25. doi: 10.4049/jimmunol.1400820. Epub 2014Aug 18.

Nityanandam R, Serra-Moreno R
BCA2/Rabring7 targets HIV-1 Gag for lysosomal degradation in atetherin-independent manner.
PLoS Pathog. 2014 May 22;10(5):e1004151. doi: 10.1371/journal.ppat.1004151.eCollection 2014 May.

Ogawa LM, Vallender EJ
Evolutionary conservation in genes underlying human psychiatric disorders.
Front Hum Neurosci. 2014 May 6;8:283. doi: 10.3389/fnhum.2014.00283. eCollection 2014.

Ogawa LM, Vallender EJ
Genetic substructure in cynomolgus macaques (Macaca fascicularis) on the islandof Mauritius.
BMC Genomics. 2014 Aug 31;15:748. doi: 10.1186/1471-2164-15-748.

Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL, Dong M
Widespread sequence variations in VAMP1 across vertebrates suggest a potentialselective pressure from botulinum neurotoxins.
PLoS Pathog. 2014 Jul 10;10(7):e1004177. doi: 10.1371/journal.ppat.1004177.eCollection 2014 Jul.

Petrosky KY, Knight HL, Westmoreland SV, Miller AD
Atypical nodular astrocytosis in simian immunodeficiency virus-infected rhesusmacaques (Macaca mulatta).
J Med Primatol. 2014 Dec;43(6):468-76. doi: 10.1111/jmp.12138. Epub 2014 Aug 1.

Postler TS, Bixby JG, Desrosiers RC, Yuste E
Systematic analysis of intracellular trafficking motifs located within thecytoplasmic domain of simian immunodeficiency virus glycoprotein gp41.
PLoS One. 2014 Dec 5;9(12):e114753. doi: 10.1371/journal.pone.0114753.eCollection 2014.

Reeves RK, Kang G, Li H, Li Q
Depletion of lamina propria innate lymphoid cells in simian immunodeficiencyvirus infection.
AIDS Res Hum Retroviruses. 2014 Dec;30(12):1160-1. doi: 10.1089/aid.2014.0293.

Ruan H, Saur T, Yao WD
Dopamine-enabled anti-Hebbian timing-dependent plasticity in prefrontalcircuitry.
Front Neural Circuits. 2014 Apr 23;8:38. doi: 10.3389/fncir.2014.00038.eCollection 2014.

Sawyer EK, Moran C, Sirbu MH, Szafir M, Van Linn M, Namjoshi O, Phani Babu Tiruveedhula VV, Cook JM, Platt DM
Little evidence of a role for the alpha1GABAA subunit-containing receptor in arhesus monkey model of alcohol drinking.
Alcohol Clin Exp Res. 2014 Apr;38(4):1108-17. doi: 10.1111/acer.12320. Epub 2013 Dec 13.

Schafer JL, Colantonio AD, Neidermyer WJ, Dudley DM, Connole M, O'Connor DH, Evans DT
KIR3DL01 recognition of Bw4 ligands in the rhesus macaque: maintenance of Bw4specificity since the divergence of apes and Old World monkeys.
J Immunol. 2014 Feb 15;192(4):1907-17. doi: 10.4049/jimmunol.1302883. Epub 2014Jan 22.

Shang L, Smith AJ, Duan L, Perkey KE, Qu L, Wietgrefe S, Zupancic M, Southern PJ, Masek-Hammerman K, Reeves RK, Johnson RP, Haase AT
NK cell responses to simian immunodeficiency virus vaginal exposure in naive and vaccinated rhesus macaques.
J Immunol. 2014 Jul 1;193(1):277-84. doi: 10.4049/jimmunol.1400417. Epub 2014 Jun4.

Smith AJ, Wietgrefe SW, Shang L, Reilly CS, Southern PJ, Perkey KE, Duan L, Kohler H, Muller S, Robinson J, Carlis JV, Li Q, Johnson RP, Haase AT
Live simian immunodeficiency virus vaccine correlate of protection: immunecomplex-inhibitory Fc receptor interactions that reduce target cell availability.
J Immunol. 2014 Sep 15;193(6):3126-33. doi: 10.4049/jimmunol.1400822. Epub 2014Aug 20.

Sundberg M, Isacson O
Advances in stem-cell--generated transplantation therapy for Parkinson's disease.
Expert Opin Biol Ther. 2014 Apr;14(4):437-53. doi: 10.1517/14712598.2014.876986.

Vallender EJ
Bringing non-human primate research into the post-genomic era: how monkeys areteaching us about elite controllers of HIV/AIDS.
Genome Biol. 2014 Nov 7;15(11):507. doi: 10.1186/s13059-014-0507-y.

Ward JM, Buslov AM, Vallender EJ
Twinning and survivorship of captive common marmosets (Callithrix jacchus) andcotton-top tamarins (Saguinus oedipus).
J Am Assoc Lab Anim Sci. 2014 Jan;53(1):7-11.

Westmoreland SV, Converse AP, Hrecka K, Hurley M, Knight H, Piatak M, Lifson J, Mansfield KG, Skowronski J, Desrosiers RC
SIV vpx is essential for macrophage infection but not for development of AIDS.
PLoS One. 2014 Jan 21;9(1):e84463. doi: 10.1371/journal.pone.0084463. eCollection2014.

Yang B, Li S, Wang H, Guo Y, Gessler DJ, Cao C, Su Q, Kramer J, Zhong L, Ahmed SS, Zhang H, He R, Desrosiers RC, Brown R, Xu Z, Gao G
Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 andrAAVrh.10 and nonhuman primates by rAAVrh.10.
Mol Ther. 2014 Jul;22(7):1299-1309. doi: 10.1038/mt.2014.68. Epub 2014 Apr 30.

Yao WD, Wu CF
Exploring the genetic underpinnings of brain and behavioral disorders.
J Neurogenet. 2014 Mar-Jun;28(1-2):1-4. doi: 10.3109/01677063.2014.908875.

Yen PJ, Mefford ME, Hoxie JA, Williams KC, Desrosiers RC, Gabuzda D
Identification and characterization of a macrophage-tropic SIV envelopeglycoprotein variant in blood from early infection in SIVmac251-infected macaques.
Virology. 2014 Jun;458-459:53-68. doi: 10.1016/j.virol.2014.03.024. Epub 2014 May8.

Zhang J, Saur T, Duke AN, Grant SG, Platt DM, Rowlett JK, Isacson O, Yao WD
Motor impairments, striatal degeneration, and altered dopamine-glutamateinterplay in mice lacking PSD-95.
J Neurogenet. 2014 Mar-Jun;28(1-2):98-111. doi: 10.3109/01677063.2014.892486.Epub 2014 Apr 22.

Zhuang K, Leda AR, Tsai L, Knight H, Harbison C, Gettie A, Blanchard J, Westmoreland S, Cheng-Mayer C
Emergence of CD4 independence envelopes and astrocyte infection in R5simian-human immunodeficiency virus model of encephalitis.
J Virol. 2014 Aug;88(15):8407-20. doi: 10.1128/JVI.01237-14. Epub 2014 May 14.

van Teijlingen NH, Holzemer A, Korner C, Garcia-Beltran WF, Schafer JL, Fadda L, Suscovich TJ, Brander C, Carrington M, Evans DT, van Baarle D, Altfeld M
Sequence variations in HIV-1 p24 Gag-derived epitopes can alter binding ofKIR2DL2 to HLA-C*03:04 and modulate primary natural killer cell function.
AIDS. 2014 Jun 19;28(10):1399-408. doi: 10.1097/QAD.0000000000000284.

Barouch DH, Stephenson KE, Borducchi EN, Smith K, Stanley K, McNally AG, Liu J, Abbink P, Maxfield LF, Seaman MS, Dugast AS, Alter G, Ferguson M, Li W, Earl PL, Moss B, Giorgi EE, Szinger JJ, Eller LA, Billings EA, Rao M, Tovanabutra S, Sanders-Buell E, Weijtens M, Pau MG, Schuitemaker H, Robb ML, Kim JH, Korber BT, Michael NL
Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIVchallenges in rhesus monkeys.
Cell. 2013 Oct 24;155(3):531-9. doi: 10.1016/j.cell.2013.09.061. Epub 2013 Oct24.

Barouch DH, Whitney JB, Moldt B, Klein F, Oliveira TY, Liu J, Stephenson KE, Chang HW, Shekhar K, Gupta S, Nkolola JP, Seaman MS, Smith KM, Borducchi EN, Cabral C, Smith JY, Blackmore S, Sanisetty S, Perry JR, Beck M, Lewis MG, Rinaldi W, Chakraborty AK, Poignard P, Nussenzweig MC, Burton DR
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys.
Nature. 2013 Nov 14;503(7475):224-8. doi: 10.1038/nature12744. Epub 2013 Oct 30.

Berntsson RP, Peng L, Dong M, Stenmark P
Structure of dual receptor binding to botulinum neurotoxin B.
Nat Commun. 2013;4:2058. doi: 10.1038/ncomms3058.

Berntsson RP, Peng L, Svensson LM, Dong M, Stenmark P
Crystal structures of botulinum neurotoxin DC in complex with its proteinreceptors synaptotagmin I and II.
Structure. 2013 Sep 3;21(9):1602-11. doi: 10.1016/j.str.2013.06.026. Epub 2013Aug 8.

Bunce JG, Zikopoulos B, Feinberg M, Barbas H
Parallel prefrontal pathways reach distinct excitatory and inhibitory systems in memory-related rhinal cortices.
J Comp Neurol. 2013 Dec 15;521(18):4260-83. doi: 10.1002/cne.23413.

Carville A, Evans TI, Reeves RK
Characterization of circulating natural killer cells in neotropical primates.
PLoS One. 2013 Nov 11;8(11):e78793. doi: 10.1371/journal.pone.0078793.eCollection 2013.

Chen GL, Miller GM
Extensive alternative splicing of the repressor element silencing transcriptionfactor linked to cancer.
PLoS One. 2013 Apr 16;8(4):e62217. doi: 10.1371/journal.pone.0062217. Print 2013.

Chen GL, Miller GM
Tryptophan hydroxylase-2: an emerging therapeutic target for stress disorders.
Biochem Pharmacol. 2013 May 1;85(9):1227-33. doi: 10.1016/j.bcp.2013.02.018. Epub2013 Feb 19.

Cummings Macri S, Knight HL, Miller AD
Mesenchymoproliferative enteropathy associated with dual simian polyomavirus and rhesus cytomegalovirus infection in a simian immunodeficiency virus-infected rhesus macaque (Macaca mulatta).
Vet Pathol. 2013 Jul;50(4):715-21. doi: 10.1177/0300985812463405. Epub 2012 Oct9.

Del Prete GQ, Scarlotta M, Newman L, Reid C, Parodi LM, Roser JD, Oswald K, Marx PA, Miller CJ, Desrosiers RC, Barouch DH, Pal R, Piatak M Jr, Chertova E, Giavedoni LD, O'Connor DH, Lifson JD, Keele BF
Comparative characterization of transfection- and infection-derived simianimmunodeficiency virus challenge stocks for in vivo nonhuman primate studies.
J Virol. 2013 Apr;87(8):4584-95. doi: 10.1128/JVI.03507-12. Epub 2013 Feb 13.

Drumond BP, Mondini A, Schmidt DJ, de Morais Bronzoni RV, Bosch I, Nogueira ML
Circulation of different lineages of Dengue virus 2, genotype American/Asian inBrazil: dynamics and molecular and phylogenetic characterization.
PLoS One. 2013;8(3):e59422. doi: 10.1371/journal.pone.0059422. Epub 2013 Mar 22.

Evans TI, Reeves RK
All-trans-retinoic acid imprints expression of the gut-homing marker alpha4beta7 while suppressing lymph node homing of dendritic cells.
Clin Vaccine Immunol. 2013 Oct;20(10):1642-6. doi: 10.1128/CVI.00419-13. Epub2013 Aug 21.

Fischer BD, Teixeira LP, van Linn ML, Namjoshi OA, Cook JM, Rowlett JK
Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acutebenzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation.
Psychopharmacology (Berl). 2013 May;227(2):347-54. doi:10.1007/s00213-013-2975-2. Epub 2013 Jan 26.

Goswami DB, Ogawa LM, Ward JM, Miller GM, Vallender EJ
Large-scale polymorphism discovery in macaque G-protein coupled receptors.
BMC Genomics. 2013 Oct 11;14:703. doi: 10.1186/1471-2164-14-703.

Hahn AS, Desrosiers RC
Rhesus monkey rhadinovirus uses eph family receptors for entry into B cells andendothelial cells but not fibroblasts.
PLoS Pathog. 2013;9(5):e1003360. doi: 10.1371/journal.ppat.1003360. Epub 2013 May16.

Harbison CE, Ellis ME, Westmoreland SV
Spontaneous cervicovaginal lesions and immune cell infiltrates in nonhumanprimates.
Toxicol Pathol. 2013;41(7):1016-27. doi: 10.1177/0192623313477754. Epub 2013 Feb 20.

Hong HS, Rajakumar PA, Billingsley JM, Reeves RK, Johnson RP
No monkey business: why studying NK cells in non-human primates pays off.
Front Immunol. 2013 Feb 18;4:32. doi: 10.3389/fimmu.2013.00032. eCollection 2013.

John YJ, Bullock D, Zikopoulos B, Barbas H
Anatomy and computational modeling of networks underlying cognitive-emotionalinteraction.
Front Hum Neurosci. 2013 Apr 2;7:101. doi: 10.3389/fnhum.2013.00101. eCollection 2013.

Kaliyaperumal S, Dang X, Wuethrich C, Knight HL, Pearson C, MacKey J, Mansfield KG, Koralnik IJ, Westmoreland SV
Frequent infection of neurons by SV40 virus in SIV-infected macaque monkeys with progressive multifocal leukoencephalopathy and meningoencephalitis.
Am J Pathol. 2013 Dec;183(6):1910-1917. doi: 10.1016/j.ajpath.2013.08.007. Epub2013 Oct 1.

Katz NP, Birnbaum H, Brennan MJ, Freedman JD, Gilmore GP, Jay D, Kenna GA, Madras BK, McElhaney L, Weiss RD, White AG
Prescription opioid abuse: challenges and opportunities for payers.
Am J Manag Care. 2013 Apr;19(4):295-302.

Leskowitz RM, Zhou XY, Villinger F, Fogg MH, Kaur A, Lieberman PM, Wang F, Ertl HC
CD4+ and CD8+ T-cell responses to latent antigen EBNA-1 and lytic antigen BZLF-1 during persistent lymphocryptovirus infection of rhesus macaques.
J Virol. 2013 Aug;87(15):8351-62. doi: 10.1128/JVI.00852-13. Epub 2013 May 22.

Li H, Evans TI, Reeves RK
Loss of bone marrow NK cells during SIV infection is associated with increasedturnover rates and cytotoxicity but not changes in trafficking.
J Med Primatol. 2013 Oct;42(5):230-6. doi: 10.1111/jmp.12063. Epub 2013 Jul 30.

Li H, Gillis J, Johnson RP, Reeves RK
Multi-functional plasmacytoid dendritic cells redistribute to gut tissues during simian immunodeficiency virus infection.
Immunology. 2013 Oct;140(2):244-9. doi: 10.1111/imm.12132.

Licata SC, Shinday NM, Huizenga MN, Darnell SB, Sangrey GR, Rudolph U, Rowlett JK, Sadri-Vakili G
Alterations in brain-derived neurotrophic factor in the mouse hippocampusfollowing acute but not repeated benzodiazepine treatment.
PLoS One. 2013 Dec 19;8(12):e84806. doi: 10.1371/journal.pone.0084806.eCollection 2013.

Lynch LJ, Sullivan KA, Vallender EJ, Rowlett JK, Platt DM, Miller GM
Trace amine associated receptor 1 modulates behavioral effects of ethanol.
Subst Abuse. 2013 Jun 4;7:117-26. doi: 10.4137/SART.S12110. Print 2013.

Madras BK
History of the discovery of the antipsychotic dopamine D2 receptor: a basis forthe dopamine hypothesis of schizophrenia.
J Hist Neurosci. 2013;22(1):62-78. doi: 10.1080/0964704X.2012.678199.

Makaron L, Moran CA, Namjoshi O, Rallapalli S, Cook JM, Rowlett JK
Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys.
Pharmacol Biochem Behav. 2013 Mar;104:62-8. doi: 10.1016/j.pbb.2012.12.018. Epub 2013 Jan 2.

Manrique J, Piatak M, Lauer W, Johnson W, Mansfield K, Lifson J, Desrosiers R
Influence of mismatch of Env sequences on vaccine protection by live attenuatedsimian immunodeficiency virus.
J Virol. 2013 Jul;87(13):7246-54. doi: 10.1128/JVI.00798-13. Epub 2013 May 1.

Martinot AJ, Meythaler M, Pozzi LA, Dalecki Boisvert K, Knight H, Walsh D, Westmoreland S, Anderson DC, Kaur A, O'Neil SP
Acute SIV infection in sooty mangabey monkeys is characterized by rapid virusclearance from lymph nodes and absence of productive infection in germinal centers.
PLoS One. 2013;8(3):e57785. doi: 10.1371/journal.pone.0057785. Epub 2013 Mar 5.

Peng L, Liu H, Ruan H, Tepp WH, Stoothoff WH, Brown RH, Johnson EA, Yao WD, Zhang SC, Dong M
Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 andSNAP-25 in neuron survival.
Nat Commun. 2013;4:1472. doi: 10.1038/ncomms2462.

Postler TS, Desrosiers RC
The tale of the long tail: the cytoplasmic domain of HIV-1 gp41.
J Virol. 2013 Jan;87(1):2-15. doi: 10.1128/JVI.02053-12. Epub 2012 Oct 17.

Rahmberg AR, Neidermyer WJ Jr, Breed MW, Alvarez X, Midkiff CC, Piatak M Jr, Lifson JD, Evans DT
Tetherin upregulation in simian immunodeficiency virus-infected macaques.
J Virol. 2013 Dec;87(24):13917-21. doi: 10.1128/JVI.01757-13. Epub 2013 Oct 9.

Ren W, Mumbauer A, Zhuang K, Harbison C, Knight H, Westmoreland S, Gettie A, Blanchard J, Cheng-Mayer C
Mucosal transmissibility, disease induction and coreceptor switching of R5SHIVSF162P3N molecular clones in rhesus macaques.
Retrovirology. 2013 Jan 31;10:9. doi: 10.1186/1742-4690-10-9.

Ruedi-Bettschen D, Rowlett JK, Rallapalli S, Clayton T, Cook JM, Platt DM
Modulation of alpha5 subunit-containing GABAA receptors alters alcohol drinkingby rhesus monkeys.
Alcohol Clin Exp Res. 2013 Apr;37(4):624-34. doi: 10.1111/acer.12018. Epub 2012Nov 5.

Sasikala-Appukuttan AK, Kim HO, Kinzel NJ, Hong JJ, Smith AJ, Wagstaff R, Reilly C, Piatak M Jr, Lifson JD, Reeves RK, Johnson RP, Haase AT, Skinner PJ
Location and dynamics of the immunodominant CD8 T cell response to SIVDeltanefimmunization and SIVmac251 vaginal challenge.
PLoS One. 2013 Dec 9;8(12):e81623. doi: 10.1371/journal.pone.0081623. eCollection2013.

Serra-Moreno R, Zimmermann K, Stern LJ, Evans DT
Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction betweenNef and tetherin, and on clathrin-mediated endocytosis.
PLoS Pathog. 2013;9(7):e1003487. doi: 10.1371/journal.ppat.1003487. Epub 2013 Jul11.

Shinday NM, Sawyer EK, Fischer BD, Platt DM, Licata SC, Atack JR, Dawson GR, Reynolds DS, Rowlett JK
Reinforcing effects of compounds lacking intrinsic efficacy at alpha1subunit-containing GABAA receptor subtypes in midazolam- but not cocaine-experienced rhesus monkeys.
Neuropsychopharmacology. 2013 May;38(6):1006-14. doi: 10.1038/npp.2012.265. Epub 2012 Dec 27.

Soltow QA, Strobel FH, Mansfield KG, Wachtman L, Park Y, Jones DP
High-performance metabolic profiling with dual chromatography-Fourier-transformmass spectrometry (DC-FTMS) for study of the exposome.
Metabolomics. 2013 Mar;9(1 Suppl):S132-S143. doi: 10.1007/s11306-011-0332-1.

Song H, Josleyn N, Janosko K, Skinner J, Reeves RK, Cohen M, Jett C, Johnson R, Blaney JE, Bollinger L, Jennings G, Jahrling PB
Monkeypox virus infection of rhesus macaques induces massive expansion of naturalkiller cells but suppresses natural killer cell functions.
PLoS One. 2013 Oct 17;8(10):e77804. doi: 10.1371/journal.pone.0077804.eCollection 2013.

Sundberg M, Bogetofte H, Lawson T, Jansson J, Smith G, Astradsson A, Moore M, Osborn T, Cooper O, Spealman R, Hallett P, Isacson O
Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons.
Stem Cells. 2013 Aug;31(8):1548-62. doi: 10.1002/stem.1415.

Tanaka T, Lerche NW, Farver TB, Ardeshir A, Kass PH
Specific-pathogen-free status is associated with lower infant mortality rate inrhesus macaque (Macaca mulatta) colonies at the California National Primate Research Center.
J Med Primatol. 2013 Aug;42(4):186-91. doi: 10.1111/jmp.12049. Epub 2013 Apr 16.

Vallender EJ
How brains are built: genetics and evolution.
Brain Behav Evol. 2013;81(2):71-3. doi: 10.1159/000347054. Epub 2013 Mar 6.

Vallender EJ, Miller GM
Nonhuman primate models in the genomic era: a paradigm shift.
ILAR J. 2013;54(2):154-65. doi: 10.1093/ilar/ilt044.

Villabona-Arenas CJ, Mondini A, Bosch I, Schimdt DJ, Calzavara-Silva CE, Zanotto PM, Nogueira ML
Dengue virus type 3 adaptive changes during epidemics in Sao Jose de Rio Preto,Brazil, 2006-2007.
PLoS One. 2013 May 7;8(5):e63496. doi: 10.1371/journal.pone.0063496. Print 2013.

Wies E, Wang MK, Maharaj NP, Chen K, Zhou S, Finberg RW, Gack MU
Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 isessential for innate immune signaling.
Immunity. 2013 Mar 21;38(3):437-49. doi: 10.1016/j.immuni.2012.11.018. Epub 2013 Mar 14.

Zikopoulos B, Barbas H
Altered neural connectivity in excitatory and inhibitory cortical circuits inautism.
Front Hum Neurosci. 2013 Sep 27;7:609. doi: 10.3389/fnhum.2013.00609. eCollection2013.

Achat-Mendes C, Lynch LJ, Sullivan KA, Vallender EJ, Miller GM
Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1.
Pharmacol Biochem Behav. 2012 Apr;101(2):201-7. doi: 10.1016/j.pbb.2011.10.025.Epub 2011 Nov 4.

Achat-Mendes C, Nic Dhonnchadha BA, Platt DM, Kantak KM, Spealman RD
Glycine transporter-1 inhibition preceding extinction training inhibitsreacquisition of cocaine seeking.
Neuropsychopharmacology. 2012 Dec;37(13):2837-45. doi: 10.1038/npp.2012.155. Epub2012 Sep 5.

Achat-Mendes C, Platt DM, Spealman RD
Antagonism of metabotropic glutamate 1 receptors attenuates behavioral effects ofcocaine and methamphetamine in squirrel monkeys.
J Pharmacol Exp Ther. 2012 Oct;343(1):214-24. doi: 10.1124/jpet.112.196295. Epub 2012 Jul 18.

Alpert MD, Harvey JD, Lauer WA, Reeves RK, Piatak M Jr, Carville A, Mansfield KG, Lifson JD, Li W, Desrosiers RC, Johnson RP, Evans DT
ADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challenge.
PLoS Pathog. 2012;8(8):e1002890. doi: 10.1371/journal.ppat.1002890. Epub 2012 Aug23.

Alpert MD, Heyer LN, Williams DE, Harvey JD, Greenough T, Allhorn M, Evans DT
A novel assay for antibody-dependent cell-mediated cytotoxicity against HIV-1- orSIV-infected cells reveals incomplete overlap with antibodies measured by neutralization and binding assays.
J Virol. 2012 Nov;86(22):12039-52. doi: 10.1128/JVI.01650-12. Epub 2012 Aug 29.

Assaf BT, Mansfield KG, Westmoreland SV, Kaur A, Oxford KL, Diamond DJ, Barry PA
Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-termRhCMV infection.
J Virol. 2012 Jun;86(11):6354-7. doi: 10.1128/JVI.00607-12. Epub 2012 Apr 4.

Assaf BT, Miller AD
Pleural endometriosis in an aged rhesus macaque (Macaca mulatta): ahistopathologic and immunohistochemical study.
Vet Pathol. 2012 Jul;49(4):636-41. doi: 10.1177/0300985811406890. Epub 2011 Apr26.

Bailey CC, Huang IC, Kam C, Farzan M
Ifitm3 limits the severity of acute influenza in mice.
PLoS Pathog. 2012 Sep;8(9):e1002909. doi: 10.1371/journal.ppat.1002909. Epub 2012Sep 6.

Bailey CC, Miller AD
Ulcerative cheilitis in a rhesus macaque.
Vet Pathol. 2012 Mar;49(2):412-5. doi: 10.1177/0300985811400443. Epub 2011 Mar 7.

Barouch DH, Liu J, Li H, Maxfield LF, Abbink P, Lynch DM, Iampietro MJ, SanMiguel A, Seaman MS, Ferrari G, Forthal DN, Ourmanov I, Hirsch VM, Carville A, Mansfield KG, Stablein D, Pau MG, Schuitemaker H, Sadoff JC, Billings EA, Rao M, Robb ML, Kim JH, Marovich MA, Goudsmit J, Michael NL
Vaccine protection against acquisition of neutralization-resistant SIV challengesin rhesus monkeys.
Nature. 2012 Jan 4;482(7383):89-93. doi: 10.1038/nature10766.

Boorman G, Crabbs TA, Kolenda-Roberts H, Latimer K, Miller AD, Muravnick KB, Nyska A, Ochoa R, Pardo ID, Ramot Y, Rao DB, Schuh J, Suttie A, Travlos GS, Ward JM, Wolf JC, Elmore SA
Proceedings of the 2011 National Toxicology Program Satellite Symposium.
Toxicol Pathol. 2012;40(2):321-44. doi: 10.1177/0192623311427713. Epub 2011 Nov16.

Braun SE, Taube R, Zhu Q, Wong FE, Murakami A, Kamau E, Dwyer M, Qiu G, Daigle J, Carville A, Johnson RP, Marasco WA
In vivo selection of CD4(+) T cells transduced with a gamma-retroviral vectorexpressing a single-chain intrabody targeting HIV-1 tat.
Hum Gene Ther. 2012 Sep;23(9):917-31. doi: 10.1089/hum.2011.184.

Chan YK, Huang IC, Farzan M
IFITM proteins restrict antibody-dependent enhancement of dengue virus infection.
PLoS One. 2012;7(3):e34508. doi: 10.1371/journal.pone.0034508. Epub 2012 Mar 30.

Chen GL, Miller GM
Advances in tryptophan hydroxylase-2 gene expression regulation: new insightsinto serotonin-stress interaction and clinical implications.
Am J Med Genet B Neuropsychiatr Genet. 2012 Mar;159B(2):152-71. doi:10.1002/ajmg.b.32023.

Chiang JJ, Gardner MR, Quinlan BD, Dorfman T, Choe H, Farzan M
Enhanced recognition and neutralization of HIV-1 by antibody-derived CCR5-mimeticpeptide variants.
J Virol. 2012 Nov;86(22):12417-21. doi: 10.1128/JVI.00967-12. Epub 2012 Aug 29.

Handley SA, Thackray LB, Zhao G, Presti R, Miller AD, Droit L, Abbink P, Maxfield LF, Kambal A, Duan E, Stanley K, Kramer J, Macri SC, Permar SR, Schmitz JE, Mansfield K, Brenchley JM, Veazey RS, Stappenbeck TS, Wang D, Barouch DH, Virgin HW
Pathogenic simian immunodeficiency virus infection is associated with expansionof the enteric virome.
Cell. 2012 Oct 12;151(2):253-66. doi: 10.1016/j.cell.2012.09.024.

Haynes BF, Gilbert PB, McElrath MJ, Zolla-Pazner S, Tomaras GD, Alam SM, Evans DT, Montefiori DC, Karnasuta C, Sutthent R, Liao HX, DeVico AL, Lewis GK, Williams C, Pinter A, Fong Y, Janes H, DeCamp A, Huang Y, Rao M, Billings E, Karasavvas N, Robb ML, Ngauy V, de Souza MS, Paris R, Ferrari G, Bailer RT, Soderberg KA, Andrews C, Berman PW, Frahm N, De Rosa SC, Alpert MD, Yates NL, Shen X, Koup RA, Pitisuttithum P, Kaewkungwal J, Nitayaphan S, Rerks-Ngarm S, Michael NL, Kim JH
Immune-correlates analysis of an HIV-1 vaccine efficacy trial.
N Engl J Med. 2012 Apr 5;366(14):1275-86. doi: 10.1056/NEJMoa1113425.

Kamperschroer C, Kaur A, Lebrec H
A summary of meeting proceedings for 'Measuring immune responses in non-humanprimates for drug development-opportunities and challenges for predicting human efficacy and immunotoxicity'.
J Immunotoxicol. 2012 Jan-Mar;9(1):108-20. doi: 10.3109/1547691X.2011.631610.

Li H, Reeves RK
Functional perturbation of classical natural killer and innate lymphoid cells in the oral mucosa during SIV infection.
Front Immunol. 2013 Jan 8;3:417. doi: 10.3389/fimmu.2012.00417. eCollection 2012.

Macri SC, Bailey CC, de Oca NM, Silva NA, Rosene DL, Mansfield KG, Miller AD
Immunophenotypic alterations in resident immune cells and myocardial fibrosis in the aging rhesus macaque (Macaca mulatta) heart.
Toxicol Pathol. 2012 Jun;40(4):637-46. doi: 10.1177/0192623311436177. Epub 2012Feb 10.

Maharaj NP, Wies E, Stoll A, Gack MU
Conventional protein kinase C-alpha (PKC-alpha) and PKC-beta negatively regulate RIG-I antiviral signal transduction.
J Virol. 2012 Feb;86(3):1358-71. doi: 10.1128/JVI.06543-11. Epub 2011 Nov 23.

Makaron L, Smith K, Bailey C, Kaliyaperumal S, Miller A, Kramer J
Immune-mediated interface dermatitis in a rhesus macaque.
J Med Primatol. 2012 Oct;41(5):332-5. doi: 10.1111/j.1600-0684.2012.00558.x. Epub2012 Aug 10.

Martinez-Navio JM, Desrosiers RC
Neutralizing capacity of monoclonal antibodies that recognize peptide sequencesunderlying the carbohydrates on gp41 of simian immunodeficiency virus.
J Virol. 2012 Dec;86(23):12484-93. doi: 10.1128/JVI.01959-12. Epub 2012 Sep 19.

Masek-Hammerman K, Miller AD, Lin KC, MacKey J, Weissenbock H, Gierbolini L, Burgos A, Perez H, Mansfield KG
Epizootic myocarditis associated with encephalomyocarditis virus in a group ofrhesus macaques (Macaca mulatta).
Vet Pathol. 2012 Mar;49(2):386-92. doi: 10.1177/0300985811409254. Epub 2011 Jun7.

Miller GM
Avenues for the development of therapeutics that target trace amine associatedreceptor 1 (TAAR1).
J Med Chem. 2012 Mar 8;55(5):1809-14. doi: 10.1021/jm201437t. Epub 2012 Jan 20.

Miller AD, Westmoreland SV, Evangelous NR, Graham A, Sledge J, Nesathurai S
Acute traumatic spinal cord injury induces glial activation in the cynomolgusmacaque (Macaca fascicularis).
J Med Primatol. 2012 Jun;41(3):202-9. doi: 10.1111/j.1600-0684.2012.00542.x.

Nic Dhonnchadha BA, Pinard E, Alberati D, Wettstein JG, Spealman RD, Kantak KM
Inhibiting glycine transporter-1 facilitates cocaine-cue extinction andattenuates reacquisition of cocaine-seeking behavior.
Drug Alcohol Depend. 2012 Apr 1;122(1-2):119-26. doi:10.1016/j.drugalcdep.2011.09.017. Epub 2011 Oct 10.

Peng L, Berntsson RP, Tepp WH, Pitkin RM, Johnson EA, Stenmark P, Dong M
Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and humansynaptotagmin II is not an effective receptor for type B, D-C and G toxins.
J Cell Sci. 2012 Jul 1;125(Pt 13):3233-42. doi: 10.1242/jcs.103564. Epub 2012 Mar27.

Postler TS, Desrosiers RC
The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-kappaBactivation through TGF-beta-activated kinase 1.
Cell Host Microbe. 2012 Feb 16;11(2):181-93. doi: 10.1016/j.chom.2011.12.005.

Postler TS, Martinez-Navio JM, Yuste E, Desrosiers RC
Evidence against extracellular exposure of a highly immunogenic region in theC-terminal domain of the simian immunodeficiency virus gp41 transmembrane protein.
J Virol. 2012 Jan;86(2):1145-57. doi: 10.1128/JVI.06463-11. Epub 2011 Nov 9.

Reeves RK, Evans TI, Gillis J, Wong FE, Kang G, Li Q, Johnson RP
SIV infection induces accumulation of plasmacytoid dendritic cells in the gutmucosa.
J Infect Dis. 2012 Nov;206(9):1462-8. doi: 10.1093/infdis/jis408. Epub 2012 Jun18.

Rout N, Greene J, Yue S, O'Connor D, Johnson RP, Else JG, Exley MA, Kaur A
Loss of effector and anti-inflammatory natural killer T lymphocyte function inpathogenic simian immunodeficiency virus infection.
PLoS Pathog. 2012 Sep;8(9):e1002928. doi: 10.1371/journal.ppat.1002928. Epub 2012Sep 20.

Serra-Moreno R, Evans DT
Adaptation of human and simian immunodeficiency viruses for resistance totetherin/BST-2.
Curr HIV Res. 2012 Jun;10(4):277-82.

Smith KA, Pearson CB, Hachey AM, Xia DL, Wachtman LM
Alternative activation of macrophages in rhesus macaques (Macaca mulatta) withendometriosis.
Comp Med. 2012 Aug;62(4):303-10.

Sweeney CG, Curran E, Westmoreland SV, Mansfield KG, Vallender EJ
Quantitative molecular assessment of chimerism across tissues in marmosets andtamarins.
BMC Genomics. 2012 Mar 19;13:98. doi: 10.1186/1471-2164-13-98.

Sweeney C, Ward J, Vallender EJ
Naturally occurring, physiologically normal, primate chimeras.
Chimerism. 2012 Apr-Jun;3(2):43-4. doi: 10.4161/chim.20729. Epub 2012 Apr 1.

Torun L, Madras BK, Meltzer PC
Synthesis and structure-activity relationship studies of3-biaryl-8-oxabicyclo[3.2.1]octane-2-carboxylic acid methyl esters.
Bioorg Med Chem. 2012 Apr 15;20(8):2762-72. doi: 10.1016/j.bmc.2012.01.053. Epub 2012 Feb 8.

Vallender EJ
Genetic correlates of the evolving primate brain.
Prog Brain Res. 2012;195:27-44. doi: 10.1016/B978-0-444-53860-4.00002-7.

Ward JM, Vallender EJ
The resurgence and genetic implications of New World primates in biomedicalresearch.
Trends Genet. 2012 Dec;28(12):586-91. doi: 10.1016/j.tig.2012.09.003. Epub 2012Oct 22.

Basu A, Li B, Mills DM, Panchal RG, Cardinale SC, Butler MM, Peet NP, Majgier-Baranowska H, Williams JD, Patel I, Moir DT, Bavari S, Ray R, Farzan MR, Rong L, Bowlin TL
Identification of a small-molecule entry inhibitor for filoviruses.
J Virol. 2011 Apr;85(7):3106-19. doi: 10.1128/JVI.01456-10. Epub 2011 Jan 26.

Bilello JP, Manrique JM, Shin YC, Lauer W, Li W, Lifson JD, Mansfield KG, Johnson RP, Desrosiers RC
Vaccine protection against simian immunodeficiency virus in monkeys usingrecombinant gamma-2 herpesvirus.
J Virol. 2011 Dec;85(23):12708-20. doi: 10.1128/JVI.00865-11. Epub 2011 Sep 7.

Birkett MA, Shinday NM, Kessler EJ, Meyer JS, Ritchie S, Rowlett JK
Acute anxiogenic-like effects of selective serotonin reuptake inhibitors areattenuated by the benzodiazepine diazepam in BALB/c mice.
Pharmacol Biochem Behav. 2011 Jun;98(4):544-51. doi: 10.1016/j.pbb.2011.03.006.Epub 2011 Mar 21.

Campbell JH, Burdo TH, Autissier P, Bombardier JP, Westmoreland SV, Soulas C, Gonzalez RG, Ratai EM, Williams KC
Minocycline inhibition of monocyte activation correlates with neuronal protectionin SIV neuroAIDS.
PLoS One. 2011 Apr 6;6(4):e18688. doi: 10.1371/journal.pone.0018688.

Colantonio AD, Bimber BN, Neidermyer WJ Jr, Reeves RK, Alter G, Altfeld M, Johnson RP, Carrington M, O'Connor DH, Evans DT
KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligandwith a Bw6 motif.
PLoS Pathog. 2011 Mar;7(3):e1001316. doi: 10.1371/journal.ppat.1001316. Epub 2011Mar 10.

Cromwell MA, Carville A, Mansfield K, Klumpp S, Westmoreland SV, Lackner AA, Johnson RP
SIV-specific CD8+ T cells are enriched in female genital mucosa of rhesusmacaques and express receptors for inflammatory chemokines.
Am J Reprod Immunol. 2011 Mar;65(3):242-7. doi: 10.1111/j.1600-0897.2010.00966.x.Epub 2011 Jan 12.

Deleidi M, Hargus G, Hallett P, Osborn T, Isacson O
Development of histocompatible primate-induced pluripotent stem cells for neural transplantation.
Stem Cells. 2011 Jul;29(7):1052-63. doi: 10.1002/stem.662.

Elemans M, Thiebaut R, Kaur A, Asquith B
Quantification of the relative importance of CTL, B cell, NK cell, and targetcell limitation in the control of primary SIV-infection.
PLoS Comput Biol. 2011 Mar;7(3):e1001103. doi: 10.1371/journal.pcbi.1001103. Epub2011 Mar 3.

Fischer BD
Preclinical assessment of drug combinations for the treatment of pain:isobolographic and dose-addition analysis of the opioidergic system.
CNS Neurol Disord Drug Targets. 2011 Aug;10(5):529-35.

Fischer BD, Atack JR, Platt DM, Reynolds DS, Dawson GR, Rowlett JK
Contribution of GABA(A) receptors containing alpha3 subunits to thetherapeutic-related and side effects of benzodiazepine-type drugs in monkeys.
Psychopharmacology (Berl). 2011 May;215(2):311-9. doi: 10.1007/s00213-010-2142-y.Epub 2010 Dec 30.

Fischer BD, Rowlett JK
Anticonflict and reinforcing effects of triazolam + pregnanolone combinations in rhesus monkeys.
J Pharmacol Exp Ther. 2011 Jun;337(3):805-11. doi: 10.1124/jpet.111.180422. Epub 2011 Mar 16.

Fofana IB, Colantonio AD, Reeves RK, Connole MA, Gillis JM, Hall LR, Sato S, Audin CR, Evans DT, Shida H, Johnson RP, Johnson WE
Flow cytometry based identification of simian immunodeficiency virus Env-specificB lymphocytes.
J Immunol Methods. 2011 Jul 29;370(1-2):75-85. doi: 10.1016/j.jim.2011.05.010.Epub 2011 Jun 13.

Gack MU
TRIMming Flavivirus infection.
Cell Host Microbe. 2011 Sep 15;10(3):175-7. doi: 10.1016/j.chom.2011.08.012.

Gokcumen O, Babb PL, Iskow RC, Zhu Q, Shi X, Mills RE, Ionita-Laza I, Vallender EJ, Clark AG, Johnson WE, Lee C
Refinement of primate copy number variation hotspots identifies candidate genomicregions evolving under positive selection.
Genome Biol. 2011;12(5):R52. doi: 10.1186/gb-2011-12-5-r52. Epub 2011 May 31.

Gupta S, Termini JM, Niu L, Kanagavelu SK, Rahmberg AR, Kornbluth RS, Evans DT, Stone GW
Latent Membrane Protein 1 as a molecular adjuvant for single-cycle lentiviralvaccines.
Retrovirology. 2011 May 18;8:39. doi: 10.1186/1742-4690-8-39.

Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, Denison MR, Choe H, Farzan M
Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus,and influenza A virus.
PLoS Pathog. 2011 Jan 6;7(1):e1001258. doi: 10.1371/journal.ppat.1001258.

Inn KS, Gack MU, Tokunaga F, Shi M, Wong LY, Iwai K, Jung JU
Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediatedtype I interferon induction.
Mol Cell. 2011 Feb 4;41(3):354-65. doi: 10.1016/j.molcel.2010.12.029.

Kingston D, Chang H, Ensser A, Lee HR, Lee J, Lee SH, Jung JU, Cho NH
Inhibition of retromer activity by herpesvirus saimiri tip leads to CD4downregulation and efficient T cell transformation.
J Virol. 2011 Oct;85(20):10627-38. doi: 10.1128/JVI.00757-11. Epub 2011 Aug 17.

Kramer JA, Mansfield KG, Simmons JH, Bernstein JA
Psychogenic alopecia in rhesus macaques presenting as focally extensive alopecia of the distal limb.
Comp Med. 2011 Jun;61(3):263-8.

Kramer JA, Sanders-Beer BE, Spano YE, Rhodes L, Mansfield KG
Hypergammaglobulinemia in an SIV-infected rhesus macaque with a B-cell neoplasmwith plasma cell differentiation.
J Med Primatol. 2011 Jun;40(3):200-4. doi: 10.1111/j.1600-0684.2011.00473.x. Epub2011 Mar 14.

Krimer PM, Miller AD, Li Q, Grosenbaugh DA, Susta L, Schatzberg SJ
Molecular and pathological investigations of the central nervous system inBorrelia burgdorferi-infected dogs.
J Vet Diagn Invest. 2011 Jul;23(4):757-63. doi: 10.1177/1040638711408281. Epub2011 Jun 13.

Kwong JA, Dorfman T, Quinlan BD, Chiang JJ, Ahmed AA, Choe H, Farzan M
A tyrosine-sulfated CCR5-mimetic peptide promotes conformational transitions inthe HIV-1 envelope glycoprotein.
J Virol. 2011 Aug;85(15):7563-71. doi: 10.1128/JVI.00630-11. Epub 2011 May 25.

Lakhashe SK, Velu V, Sciaranghella G, Siddappa NB, Dipasquale JM, Hemashettar G, Yoon JK, Rasmussen RA, Yang F, Lee SJ, Montefiori DC, Novembre FJ, Villinger F, Amara RR, Kahn M, Hu SL, Li S, Li Z, Frankel FR, Robert-Guroff M, Johnson WE, Lieberman J, Ruprecht RM
Prime-boost vaccination with heterologous live vectors encoding SIV gag andmultimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges.
Vaccine. 2011 Aug 5;29(34):5611-22. doi: 10.1016/j.vaccine.2011.06.017. Epub 2011Jul 14.

Licata SC, Rowlett JK
Self-administration of bretazenil under progressive-ratio schedules: behavioraleconomic analysis of the role intrinsic efficacy plays in the reinforcing effects of benzodiazepines.
Drug Alcohol Depend. 2011 Jan 15;113(2-3):157-64. doi:10.1016/j.drugalcdep.2010.07.019. Epub 2010 Aug 30.

Madras BK
Candidate performance measures for screening for, assessing, and treatingunhealthy substance use in hospitals.
Ann Intern Med. 2011 Jan 4;154(1):72-3; author reply 73-4. doi:10.7326/0003-4819-154-1-201101040-00016.

Meythaler M, Wang Z, Martinot A, Pryputniewicz S, Kasheta M, McClure HM, O'Neil SP, Kaur A
Early induction of polyfunctional simian immunodeficiency virus (SIV)-specific T lymphocytes and rapid disappearance of SIV from lymph nodes of sooty mangabeys during primary infection.
J Immunol. 2011 May 1;186(9):5151-61. doi: 10.4049/jimmunol.1004110. Epub 2011Mar 25.

Miller GM
The emerging role of trace amine-associated receptor 1 in the functionalregulation of monoamine transporters and dopaminergic activity.
J Neurochem. 2011 Jan;116(2):164-76. doi: 10.1111/j.1471-4159.2010.07109.x.

Moldt B, Schultz N, Dunlop DC, Alpert MD, Harvey JD, Evans DT, Poignard P, Hessell AJ, Burton DR
A panel of IgG1 b12 variants with selectively diminished or enhanced affinity forFcgamma receptors to define the role of effector functions in protection against HIV.
J Virol. 2011 Oct;85(20):10572-81. doi: 10.1128/JVI.05541-11. Epub 2011 Aug 17.

Moreland AJ, Guethlein LA, Reeves RK, Broman KW, Johnson RP, Parham P, O'Connor DH, Bimber BN
Characterization of killer immunoglobulin-like receptor genetics andcomprehensive genotyping by pyrosequencing in rhesus macaques.
BMC Genomics. 2011 Jun 7;12:295. doi: 10.1186/1471-2164-12-295.

Peng L, Tepp WH, Johnson EA, Dong M
Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides asreceptors.
PLoS Pathog. 2011 Mar;7(3):e1002008. doi: 10.1371/journal.ppat.1002008. Epub 2011Mar 31.

Platt DM, Bano KM
Opioid receptors and the discriminative stimulus effects of ethanol in squirrelmonkeys: Mu and delta opioid receptor mechanisms.
Eur J Pharmacol. 2011 Jan 10;650(1):233-9. doi: 10.1016/j.ejphar.2010.09.064.Epub 2010 Oct 15.

Platt DM, Carey G, Spealman RD
Models of neurological disease (substance abuse): self-administration in monkeys.
Curr Protoc Pharmacol. 2011 Dec;Chapter 10:Unit10.5. doi:10.1002/0471141755.ph1005s56.

Purushotham M, Sheri A, Pham-Huu DP, Madras BK, Janowsky A, Meltzer PC
The synthesis and biological evaluation of 2-(3-methyl or3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes.
Bioorg Med Chem Lett. 2011 Jan 1;21(1):48-51. doi: 10.1016/j.bmcl.2010.11.076.Epub 2010 Nov 21.

Radoshitzky SR, Warfield KL, Chi X, Dong L, Kota K, Bradfute SB, Gearhart JD, Retterer C, Kranzusch PJ, Misasi JN, Hogenbirk MA, Wahl-Jensen V, Volchkov VE, Cunningham JM, Jahrling PB, Aman MJ, Bavari S, Farzan M, Kuhn JH
Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry.
J Virol. 2011 Sep;85(17):8502-13. doi: 10.1128/JVI.02600-10. Epub 2011 Jun 22.

Ratai EM, Pilkenton S, He J, Fell R, Bombardier JP, Joo CG, Lentz MR, Kim WK, Burdo TH, Autissier P, Annamalai L, Curran E, O'Neil SP, Westmoreland SV, Williams KC, Masliah E, Gilberto Gonzalez R
CD8+ lymphocyte depletion without SIV infection does not produce metabolicchanges or pathological abnormalities in the rhesus macaque brain.
J Med Primatol. 2011 Oct;40(5):300-9. doi: 10.1111/j.1600-0684.2011.00475.x. Epub2011 Apr 4.

Reeves RK, Evans TI, Fultz PN, Johnson RP
Potential confusion of contaminating CD16+ myeloid DCs with anergic CD16+ NKcells in chimpanzees.
Eur J Immunol. 2011 Apr;41(4):1070-4. doi: 10.1002/eji.201040832. Epub 2011 Mar1.

Reeves RK, Evans TI, Gillis J, Wong FE, Connole M, Carville A, Johnson RP
Quantification of mucosal mononuclear cells in tissues with a fluorescentbead-based polychromatic flow cytometry assay.
J Immunol Methods. 2011 Mar 31;367(1-2):95-8. doi: 10.1016/j.jim.2011.02.002.Epub 2011 Feb 18.

Reeves RK, Rajakumar PA, Evans TI, Connole M, Gillis J, Wong FE, Kuzmichev YV, Carville A, Johnson RP
Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promotecytotoxic potential in NKp44+ mucosal NK cells during SIV infection.
Blood. 2011 Sep 22;118(12):3321-30. doi: 10.1182/blood-2011-04-347260. Epub 2011 Jul 26.

Rockx B, Brining D, Kramer J, Callison J, Ebihara H, Mansfield K, Feldmann H
Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection.
J Virol. 2011 Aug;85(15):7658-71. doi: 10.1128/JVI.00473-11. Epub 2011 May 18.

Rowlett JK, Kehne JH, Sprenger KJ, Maynard GD
Emergence of anti-conflict effects of zolpidem in rhesus monkeys followingextended post-injection intervals.
Psychopharmacology (Berl). 2011 Apr;214(4):855-62. doi:10.1007/s00213-010-2093-3. Epub 2010 Nov 20.

Santos RV, Lin KC, Mansfield K, Wachtman LM
Specific pathogen-free status alters immunophenotype in rhesus macaques:implications for the study of simian immunodeficiency virus.
AIDS Res Hum Retroviruses. 2011 Oct;27(10):1033-42. doi: 10.1089/AID.2010.0155.Epub 2011 Apr 3.

Serra-Moreno R, Jia B, Breed M, Alvarez X, Evans DT
Compensatory changes in the cytoplasmic tail of gp41 confer resistance totetherin/BST-2 in a pathogenic nef-deleted SIV.
Cell Host Microbe. 2011 Jan 20;9(1):46-57. doi: 10.1016/j.chom.2010.12.005.

Shin YC, Desrosiers RC
Rhesus monkey rhadinovirus ORF57 induces gH and gL glycoprotein expressionthrough posttranscriptional accumulation of target mRNAs.
J Virol. 2011 Aug;85(15):7810-7. doi: 10.1128/JVI.00493-11. Epub 2011 May 25.

Stansell E, Canis K, Haslam SM, Dell A, Desrosiers RC
Simian immunodeficiency virus from the sooty mangabey and rhesus macaque ismodified with O-linked carbohydrate.
J Virol. 2011 Jan;85(1):582-95. doi: 10.1128/JVI.01871-10. Epub 2010 Oct 20.

Suzuki T, Zhang J, Miyazawa S, Liu Q, Farzan MR, Yao WD
Association of membrane rafts and postsynaptic density: proteomics, biochemical, and ultrastructural analyses.
J Neurochem. 2011 Oct;119(1):64-77. doi: 10.1111/j.1471-4159.2011.07404.x. Epub2011 Aug 22.

Tasca S, Zhuang K, Gettie A, Knight H, Blanchard J, Westmoreland S, Cheng-Mayer C
Effect of B-cell depletion on coreceptor switching in R5 simian-humanimmunodeficiency virus infection of rhesus macaques.
J Virol. 2011 Apr;85(7):3086-94. doi: 10.1128/JVI.02150-10. Epub 2011 Jan 19.

Vallender EJ
Comparative genetic approaches to the evolution of human brain and behavior.
Am J Hum Biol. 2011 Jan-Feb;23(1):53-64. doi: 10.1002/ajhb.21132.

Vallender EJ
Expanding whole exome resequencing into non-human primates.
Genome Biol. 2011 Sep 14;12(9):R87. doi: 10.1186/gb-2011-12-9-r87.

Wachtman LM, Kramer JA, Miller AD, Hachey AM, Curran EH, Mansfield KG
Differential contribution of dietary fat and monosaccharide to metabolic syndromein the common marmoset (Callithrix jacchus).
Obesity (Silver Spring). 2011 Jun;19(6):1145-56. doi: 10.1038/oby.2010.303. Epub 2010 Dec 16.

Wachtman LM, Miller AD, Xia D, Curran EH, Mansfield KG
Colonization with nontuberculous mycobacteria is associated with positivetuberculin skin test reactions in the common marmoset (Callithrix jacchus).
Comp Med. 2011 Jun;61(3):278-84.

Westmoreland SV, Annamalai L, Lentz MR, Ratai EM, Assaf B, Boisvert K, Huynh T, Vallender EJ, Miller GM, Madras BK, Gonzalez RG
Growth-associated protein-43 and ephrin B3 induction in the brain of adultSIV-infected rhesus macaques.
J Neurovirol. 2011 Oct;17(5):455-68. doi: 10.1007/s13365-011-0047-0. Epub 2011Jul 26.

Zhuang K, Finzi A, Tasca S, Shakirzyanova M, Knight H, Westmoreland S, Sodroski J, Cheng-Mayer C
Adoption of an "open" envelope conformation facilitating CD4 binding andstructural remodeling precedes coreceptor switch in R5 SHIV-infected macaques.
PLoS One. 2011;6(7):e21350. doi: 10.1371/journal.pone.0021350. Epub 2011 Jul 8.

Barouch DH, O'Brien KL, Simmons NL, King SL, Abbink P, Maxfield LF, Sun YH, La Porte A, Riggs AM, Lynch DM, Clark SL, Backus K, Perry JR, Seaman MS, Carville A, Mansfield KG, Szinger JJ, Fischer W, Muldoon M, Korber B
Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responsesin rhesus monkeys.
Nat Med. 2010 Mar;16(3):319-23. doi: 10.1038/nm.2089. Epub 2010 Feb 21.

Kirmaier A, Wu F, Newman RM, Hall LR, Morgan JS, O'Connor S, Marx PA, Meythaler M, Goldstein S, Buckler-White A, Kaur A, Hirsch VM, Johnson WE
TRIM5 suppresses cross-species transmission of a primate immunodeficiency virusand selects for emergence of resistant variants in the new species.
PLoS Biol. 2010 Aug 24;8(8). doi: 10.1371/journal.pbio.1000462.

Xu TX, Yao WD
D1 and D2 dopamine receptors in separate circuits cooperate to drive associative long-term potentiation in the prefrontal cortex.
Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16366-71. doi:10.1073/pnas.1004108107. Epub 2010 Aug 30.

Liu J, O'Brien KL, Lynch DM, Simmons NL, La Porte A, Riggs AM, Abbink P, Coffey RT, Grandpre LE, Seaman MS, Landucci G, Forthal DN, Montefiori DC, Carville A, Mansfield KG, Havenga MJ, Pau MG, Goudsmit J, Barouch DH
Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys.
Nature. 2009 Jan 1;457(7225):87-91. doi: 10.1038/nature07469. Epub 2008 Nov 9.

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